I-REJEON PCL Filler Injection Anti-wrinkle iphakamisa nokuqinisa
Umsuka we-REJEON PCL
Eminyakeni engu-20 edlule, ukuqonda kwethu enye yezindawo eziyinkimbinkimbi kakhulu emzimbeni womuntu - ubuso - kuye kwaba ngcono kakhulu, njengoba sekuhlonzwe izakhiwo eziningana ze-anatomical.
Ngesikhathi esifanayo, i-plethora yokungahlinzeki
izinqubo sezikhona zokwelashwa
izimpawu zokuguga nokubuyisela intsha
ukubonakala kobuso. I-REJEON ingeyokuqala, futhi
okwamanje iyona kuphela, i-collagen sti mulator eyenziwe nge-polycaprolactone microspheres, enomthelela ekuthuthukisweni kwayo kobuhle okuhlala njalo. REJEON
izici eziyingqayizivele zisho ukuthi inketho efiselekayo yohlu lwezinqubo zezicubu ezithambile.
Isifinyezo
Ukwakhiwa kwe-REJ EO N ,
7 0 % CMC- esekelwe emanzini
othwala ijelifuthi3 0% PCL
ukwakheka,ivumela
umphumela wokugcwalisa ngokushesha
okubangelwa i-CMC, kulandelwa ukukhuthazwa kwe-collagen yomzimba (neocollagenesis) .
I-CMC ihlelwe kabusha 2 kuya ku-3
izinyanga ngemuva kokujovafuthi ngokuqhubekayo kungena esikhundleni sesiguli
i-collagen (ikakhulukazi uhlobo I) olukhuthazwa yi
PCL microspheres. Ama-microspheres we-PCL nawo ayakwazi ukutholakala nge-bioresorbable.
I-REJEON inenani lezimfanelo eziyenza ibe inketho ekhangayo njengesigcwalisi se-dermal:
①Ukufakwa kwe-polymer microspheres, kungakapheli inyanga eyi-1, kanye nesikafula se-collagen esihlotshaniswayo kuvimbela ukusabela kokuvuvukala ukuthi kungenzeki13
②Uhlobo lwe-collagen oluhlala njalo endaweni ejoviwe ikakhulukazi 'i-collagen ekhulile' yescaffold yohlobo lwe-collagen I5
a) Ukuncishiswa kohlobo lwe-collagen III kusho ukuthi akukho okunye ukukhuthazwa kwempendulo yokuvuvukala
③Ukucekelwa phansi kwezakhi ze-REJEON kuqedwa nge-hydrolysis, okushiya amanzi kanye ne-carbon dioxide
④Ngenxa yokuthi ivolumu yokugcina ngaphakathi kwendawo eselashwayo inkulu kunevolumu ye-Ellansé ejovwe, asikho isidingo 'sokuthinta' ukwelashwa.
a) Ivolumu yokugcina inkulu kunevolumu ejovwe ngo-20-30% ngenxa yokwakheka kwe-collagen yohlobo I-fibres11
⑤Ukutholakala kwezinguqulo ezimbili ze-REJEON ezinobude besikhathi obuhlukile besenzo kusho ukuthi ubude bomphumela wokwelashwa bungavunyelaniswa nesiguli
izidingo
a) Lokhu kufezwa ngokushintsha ubude bamaketanga e-PCL, okuvumela i-bioresorption ebikezelwe, elawulwayo futhi eguquguqukayo.
⑥Indlela yokwelapha iyafana ngokunganaki umkhiqizo we-REJEON okhethiwe a) Kuyafana:
● Izici ze-Rheological
● Isu
● Isirinji
● Inaliti/i-cannula
I-REJEON PCL Ukwakheka okuyingqayizivele
I-REJEON PCL yenziwe ngendlela ehlukile, enelungelo lobunikazi
hlanganisa:
● 7 0 % i-carboxymethyl cellulose ( CMC) - isithwali sejeli esisekelwe
● 3 0 % polycaprolactone ( PCL) microspheres ( Umfanekiso 1.4 ) 3, 4, 5
I-PCL microspheres ibanjelwe ngaphakathi
ukumiswa okulinganayo kusithwali sejeli esisekelwe ku-CMC. I-PCL ne-CMC zombili zinephrofayili enhle kakhulu nefakazelwe ye-biocompatibility.
I-REJEON PCL izinto zokusetshenziswa zivela kwaGemany
I-PCL MICROSPHERES
I-PCL iyi-polyester yezokwelapha engenabuthi, eyaqala ukwenziwa ekuqaleni kwawo-1930s4, okungukuthi.
ekhangayo ukuze isetshenziswe ku-dermal fillers ngenxa yokulula kwayo i-bioresorption; ngokwemvelo i-hydrolysed ibe yi-carbon dioxide nasemanzini ngaphakathi komzimba5.
I-PCL microspheres esetshenziswa ku
I-RE JEON yakhelwe ukunikeza
ukufaneleka kwe-biocompatibility6. Zinobuso obushelelezi, a
umumo oyindilinga nosayizi we
cishe 25-50 μm
I-PCL inephrofayili yokuphepha enhle kakhulu3 futhi isetshenziswe emkhakheni wezokwelapha iminyaka engaphezu kwengu-70 ezinhlobonhlobo zezinhlelo zokusebenza, kusukela ekuthunjweni kuya kwezicubu nokushintshwa kwezitho ngokuphrinta kwe-3D (Umfanekiso 1.6)4. Ibuye isetshenziswe ku-CE-imakwe kanye ne-US Food and
Drug Administration (FDA)- imikhiqizo egunyaziwe.
IZIMPAHLA ZAMA-CMC
I-CMC iyimpahla yemvelo etholakala ku-cellulose; ayihlangene, futhi ayinabo ubuthi. Ezinye izakhiwo zayo zihlanganisa (Umfanekiso 1.7)4 :
● Kuyisithako semithi esaziwayo
● I-hygroscopic
● Iqokwe yi-FDA njengevame ukuqashelwa njengephephile ( GRAS)
● Ukubuyisela kabusha kwenzeka ezinyangeni ezi-2 - 3
Izinzuzo ezibalulekile ze-REJEON PCL Filler
I-REJEON PCL ine-microsphere eyingqayizivele nephelele, enosayizi wezinhlayiyana ohlangabezana nezindinganiso zokuphepha zamazwe ngamazwe kanye nendawo ebushelelezi engakhuthaza ngokuqhubekayo ukukhula kwe-collagen.
Ukukhuthazwa kwe-Collagen ngu-REJEON:Ubufakazi besayensi
I-REJEON bekulokhu
ihlolwe esilwaneni
imodeli lapho onogwaja babejovwe ngawo
noma REJEON S
(PCL-1) noma i-REJEON M (PCL-2) ukuze iphenye i-neocollagenesis5.
Izinyanga eziyisishiyagalolunye ngemuva kokujova i-PCL-1,
I-neocollagenesis yayenzekile futhi i-PCL microspheres ye-PCL- 1 yayivuselelwe ngokuphelele (Umfanekiso 1. 1 1) 5.
Phakathi naleso sikhathi, nge-PCL-2 ezinyangeni ze-9,
kwakukhona ubufakazi bokubunjwa kwe
thayipha I bese uthayipha i-collagen III nxazonke
PCL microspheres. Ezinyangeni ze-2 1 ngemuva komjovo, i-PCL- 2 microspheres yayisekhona ku-tissue ejojowe5.
Ocwaningweni lokuhlola lwe-RE JEO N kubantu, iziguli zabhaliswa ukuze zithole u-Ellansé ejovwe nge-intradermally ethempelini.
isifunda9. Ukuhlaziywa kwe-histological kwezicubu ezitholwe kuma-biopsies kwembulwe
ukwakheka kwe-collagen ezungeze izinhlayiya ze-PCL ezijovwe (Umfanekiso 1. 12) 9, osekela ukutholwa okufanayo okuboniswe ngaphambilini
izicubu zikanogwaja5.
REJEON indlela yokwenza
I-REJEON inezigaba ezimbili ezihlukene zomsebenzi (Umfanekiso 1.9)1,4 :
● Isinyathelo 1: Ngokushesha ngemva komjovo, ingxenye ye-CMC inikeza ivolumu yesikhashana,
okwehla kancane kancane ezinyangeni ezi-2-3
● Isinyathelo sesi-2: I-PCL microspheres induce
i-neocollagenesis yezinhlobo ze-collagen I kanye ne-III, ene-collagen yohlobo oluphikelela kakhulu
isakhiwo sikhula kancane kancane ngaphezu kwezinyanga ezingu-1 - 3 kanye nama-PCL microspheres
ukufakwa kuhlobo lwe-collagen I
isikafula. Ivolumu ye-collagen ewumphumela
ithatha indawo yokukhuphuka kwevolumu yokuqala okubangelwa ijeli ye-CMC
I-scaffold ye-collagen ekhuthazwa yi-PCL
ama-microspheres aphikelela ngemva kokufakwa kabusha, okuholela ekwenyukeni kwevolumu okuhlala isikhathi eside okubonwa nge-REJEON
I-REJEON PCL Filler inemiphumela emihle
I-REJEON PCL Filler iyi-ejenti yokugcwalisa ehlala isikhathi eside engakwazi ukushelela imikhondo eshiywe yisikhathi futhi ibuyisele ukubukeka okugcwele nobusha ebusweni.
IMPENDULO YEKHASIMENDE YEREJEON PCL
Sihlose ukwabelana ngobungcweti bethu futhi
ulwazi lokuthi ungayifaka nini futhi kanjani i-r ej eon ekusebenzeni komtholampilo. Ngethemba ukuthi izozuzisa umfundi ngendlela efanayo engisebenzele ngayo eminyakeni eyi-10 edlule: ukunikeza ukwelashwa okuphephile okunomphumela ongcono kanye nemiphumela ehlala isikhathi eside. I-RE JEON iyithuluzi eliyisisekelo ekusebenzeni kwami futhi ingenze ngaba umjovo ongcono! ”
UDkt Francisco de Melo
Udokotela Ohlinza Ngepulasitiki, e-UAE
“I-RE JEON bekuyintandokazi yami yokugcwalisa i-dermal
Iminyaka engu-7. Le ncwadi izokusiza ukwazi ukusebenzisa kahle
RE JEON futhi uzoyithanda. ”
UDkt Shang-Li Lin
Udokotela Wesikhumba, e-Taiwan
“Ukuthuthukiswa kwesakhiwo nesikhumba
ikhwalithi evela ku-RE JOE N 's unique
I-neocollagenesis ayifani. Ngokungangabazeki elinye lamathuluzi angcono kakhulu emitholampilo efuna ukusebenza kahle nokuphepha emkhiqizweni ojovwayo. I-REJ EO N ine-
amandla okuhlinzeka ngokuphakamisa okuhlala isikhathi eside kanye nesakhiwo sobuso esithuthukisiwe ngeseshini eyodwa nje. ”
UDkt Ingrid Ló pez- Gehrke
I-Dermatologist, Mexico
“Ngithola injabulo enkulu ekusebenziseni i-RE JEON ngenxa yomphumela wayo wokucula we-vol umi omangalisayo. Lokhu kuvumela okuncane
umkhiqizo ozosetshenziswa, futhi ngokukhiqizwa kwangempela kohlobo lwe-collagen I, unamandla weqiniso wesikhumba
ukuvuselelwa. Iziguli eziningi zithi kimi: 'Ngiyaqala ngqa
Nginokuthile okuhlala isikhathi eside', noma 'Bheka ikhwalithi yesikhumba sami'. Impela isigcwalisi engisithandayo. ”
UDkt Pierre Nicolau
Udokotela Ohlinza Ngepulasitiki, eSpain
I-REJEON AMAMILESTONE AMAJOR
Ukulandela ucwaningo olubanzi nentuthuko, kanye nomtholampilo
ukuhlolwa, i-REJEON ithole isitifiketi se-ISO 13485 Quality Management System ku
20081 (Umdwebo 1.2). Ngo-2009, ukugunyazwa kwe-European Conformity (CE) kwaba
inikezwe, eholayo
ekwethulweni okuyimpumelelo okukhulu kwe
umkhiqizo e-UK, Germany naseSpain. Kwalandela okunye ukwethulwa, okubhaliswe kwabangaphezu kuka-69
amazwe ngo-2018. Ngo-2019, i
Isikhumbuzo seminyaka engu-10 sokulahlwa, ngaphezulu
sekuthengisiwe imijovo engaphezu kwesigidi
emhlabeni wonke. Kodwa indaba yempumelelo ayigcinanga lapho, nesiza esisha sokukhiqiza eNetherlands siqala
ukukhiqizwa ngo-2020
I-REJEON PCL PRODUCT Imininingwane
1ml/isiqephu
Yamukela ukupakishwa okwenziwe ngezifiso kwe-OEM
